Exposing a possible Achilles’ heel in Gram-negative bacteria

Pseudomonas_aeruginosa_Gram neg
Pseudomonas aeruginosa, a Gram-negative bacteria that can cause 
pneumonia as well as other diseases.

Multidrug resistant bacterial infections are a major biomedical problem. In the US, drug resistant bacteria infect more than 2 million people, resulting in over 20,000 deaths. For this reason, the development of new antibiotics that target these organisms is a priority for the pharmaceutical industry and government agencies.

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Graduate Student Snapshot: Michael Skirpan

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Currently a PhD candidate in the computer science department working with Tom Yeh, Michael studies how to visualize and analyze large data. With a philosophy and education background, he has a keen interest in starting a school based on democratic learning environments. He has also accomplished what many people attempt, but few succeed at: blending the worlds of science and art. In his quest to blend the two, Michael is working on an art proposal that will bring STEM and art majors together.

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How Salmonella Typhimurium survives in host macrophages by forcing them to eat blood

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An example of hemophagocytosis.

Salmonella enterica is a bacterial pathogen notorious for causing food poisoning symptoms that are uncomfortable at best and deadly at worst. Infamously linked to raw eggs, it is the reason many of us were cruelly prevented from licking cake batter right off the spoon when we were younger. Many will also recognize S. enterica for its role in typhoid fever, an infection that is most prevalent in the developing world where sanitation is limited.

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DAT isn’t all that: Cocaine also activates immune cells in the brain, increasing reward and addiction

You’ve probably heard of dopamine before. Whether you know every region of the brain by heart or are still learning how to tell gray matter from the spinal cord, dopamine is likely on your mental radar. As this fun (and informative) article from Slate describes, dopamine is involved in experiences of pleasure, reward, love, and addiction, among other processes in the brain. It’s kind of a big deal. Dopamine isn’t love or addiction itself: how dopamine shapes these experiences is complex and not yet fully understood.

dope

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